Support program for ISENTRESS® (raltegravir tablets)

I am thinking about starting HIV therapy.

I am on my first HIV regimen.

I have been on HIV therapy for a long time.

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A Program of Reimbursement Support and Patient Assistance Services

To ease the health care reimbursement process, the SUPPORT™ Program was designed to help patients who have been prescribed ISENTRESS.

The SUPPORT™ Program is a 2-part program that consists of free reimbursement support services and a patient assistance program for eligible individuals through a single toll-free call to 1-800-850-3430, Monday through Friday, 9 am to 6 pm ET. In addition, callers can leave a confidential message 24 hours a day.

1. Reimbursement Support Services^a
SUPPORT™ Program Specialists will help you and your Health Care Provider answer questions related to insurance coverage and reimbursement.

2. Patient Assistance for Eligible Patients^b
A Program Specialist can help you apply for the patient assistance program, which provides ISENTRESS free of charge to eligible patients who do not have insurance coverage.

For more information please visit: merck.com/merckhelps/support-program.

^aReimbursement Support Services are offered through Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc.

^bPatient Assistance Services are offered through the Merck Patient Assistance Program, Inc.

ISENTRESS is an anti-HIV medicine used for the treatment of HIV. ISENTRESS must be used with other anti-HIV medicines, which may increase the likelihood of response to treatment. It is important that you remain under your doctor’s care. ISENTRESS will NOT cure HIV infection or reduce your chances of passing HIV to others through sexual contact, sharing needles, or being exposed to your blood.

The safety and effectiveness of ISENTRESS in children has not been studied.

A condition called Immune Reconstitution Syndrome can happen in some patients with advanced HIV infection (AIDS) when anti-HIV treatment is started. Signs and symptoms of inflammation from opportunistic infections may occur as the medicines work to treat the HIV infection and strengthen the immune system. Call your doctor right away if you notice any signs or symptoms of an infection after starting ISENTRESS.

Contact your doctor immediately if you experience unexplained muscle pain, tenderness, or weakness while taking ISENTRESS. This is because on rare occasions muscle problems can be serious and can lead to kidney damage.

When ISENTRESS has been given with other anti-HIV drugs, side effects included nausea, headache, tiredness, weakness, trouble sleeping, stomach pain, dizziness, depression, and suicidal thoughts and actions. Other side effects include: rash, severe skin reactions, feeling anxious, paranoia, low blood platelet count, diarrhea, liver failure.

Mild rash occurred more often in patients taking ISENTRESS plus Prezista than with either drug alone.

People taking ISENTRESS may still develop infections, including opportunistic infections or other conditions that occur with HIV infection.

Tell your doctor about all of your medical conditions, including if you have any allergies, are pregnant or plan to become pregnant, or are breast-feeding or plan to breast-feed. ISENTRESS is not recommended for use during pregnancy. Women with HIV should not breast-feed because their babies could be infected with HIV through their breast milk.

Tell your doctor about all the medicines you take, including prescription medicines like rifampin (a medicine used to treat infections such as tuberculosis), non-prescription medicines, vitamins, and herbal supplements.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please read the Prescribing Information and the Patient Product Information.

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