Make A Plan And Follow It Through

HOW TO TAKE ISENTRESS (raltegravir) 400 mg FILM-COATED
TABLETS

You may have so much going on that it may be hard to remember how and when
you're supposed to take your medicines. Click the sections below to learn how to:

  • Take ISENTRESS exactly as your healtcare professional prescribed.
    Remember to:

    • Take it twice a day
    • Take it by mouth. Film-coated tablets must be swallowed whole
    • Take it with or without food
    • If you miss a dose, take it as soon as you remember. If you do not remember until it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double your next dose or take more than your prescribed dose
    • Store it at room temperature (68° to 77° F). ISENTRESS does not require refrigeration
    • Do not run out of ISENTRESS. Get your ISENTRESS refilled from your healthcare professional or pharmacy before you run out
  • Tips for remembering to take your meds:

    • Organize pills by day and time
    • Keep a note pad near your dresser
    • Put sticky notes on your mirror
    • Write it down on a calendar
    • Make taking your medication part of your daily routine (eg, when brushing your teeth or taking it at meal time)
    • Join a program that sends reminders to your cell phone or computer
    • Ask friends/family for help
    • Download our free easy-to-use treatment management apps (desktop and mobile) that can help remind you to take your medications on time

Download a free app to track symptoms and side effects, and manage your medicine schedule. The app is available for desktops and mobile phones.

Download "My Positive
Agenda" to your desktop.

Compatible with both PC and Mac
Download
[Requires >1 MB of disk space.]

Download the mobile version
of "My Health Matters".

ISENTRESS is an HIV medicine that, when used with other HIV medicines,
may reduce the amount of HIV in your blood and help increase
the number of CD4 (T) cells.


IMPORTANT RISK
INFORMATION:

Tell your doctor about all the medicines
you take, including: prescription
medicines like rifampin (a medicine
commonly use to treat tuberculosis),
non-prescription medicines, vitamins,
and herbal supplements.
Especially tell your doctor if you take antacids, as certain antacids (those containing aluminum and/or magnesium) are not recommended to be taken with ISENTRESS.

Click here for more important risk
information about ISENTRESS

ISENTRESS is a prescription HIV-1 medicine used with other HIV medicines to treat adults with human immunodeficiency virus (HIV-1) infection. HIV is the virus that causes AIDS (Acquired Immune Deficiency Syndrome).

The use of other medicines active against HIV-1 in combination with ISENTRESS may increase your ability to fight HIV.

ISENTRESS does not cure HIV infection or AIDS.

Patients must stay on continuous HIV therapy to control infection and decrease HIV-related illnesses.

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IMPORTANT RISK INFORMATION:

Severe, potentially life-threatening, and fatal skin reactions and allergic reactions have been reported in some patients taking ISENTRESS. If you develop a rash with any of the following symptoms, stop using ISENTRESS and contact your doctor right away: fever, generally ill feeling, extreme tiredness, muscle or joint aches, blisters or sores in mouth, blisters or peeling of skin, redness or swelling of the eyes, swelling of the mouth or face, problems breathing.

Sometimes allergic reactions can affect body organs, like the liver. Contact your doctor right away if you have any of the following signs or symptoms of liver problems: yellowing of the skin or whites of the eyes, dark or tea-colored urine, pale-colored stools/bowel movements, nausea/vomiting, loss of appetite, pain, aching or tenderness on the right side below the ribs.

Changes in your immune system (Immune Reconstitution Syndrome) can happen when you start taking HIV medicines. Your immune system may get stronger and begin to fight infections that have been hidden in your body for a long time. Tell your doctor right away if you start having new symptoms after starting your HIV medicine.

People taking ISENTRESS may still develop infections or other conditions associated with HIV infections.

The most common side effects of ISENTRESS include: dizziness, headache, nausea, tiredness and trouble sleeping. Less common side effects include: allergic reaction, depression, hepatitis, genital herpes, herpes zoster including shingles, kidney failure, kidney stones, stomach pain, suicidal thoughts and actions, vomiting and weakness.

Tell your doctor before beginning ISENTRESS if you have a history of muscle disorders (rhabdomyolysis or myopathy) or increased creatine kinase or if you are taking medications known to cause these conditions such as statins, fenofibrate, gemfibrozil or zidovudine.

Tell your doctor right away if you get unexplained muscle pain, tenderness, or weakness while taking ISENTRESS. This may be a sign of a rare but serious muscle problem that can lead to kidney problems.

Rash occurred more often in patients taking ISENTRESS and darunavir/ritonavir (Prezista) together, than with either drug separately, but was generally mild.

These are not all the possible side effects of ISENTRESS. For more information, ask your doctor or pharmacist. Tell your doctor if you have any side effect that bothers you or that does not go away.

Tell your doctor about all your medical conditions, including if you have any allergies, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. ISENTRESS is not recommended for use during pregnancy. Women with HIV should not breastfeed because their babies could be infected with HIV through their breast milk.

Tell your doctor about all the medicines you take, including: prescription medicines like rifampin (a medicine commonly used to treat tuberculosis), non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take antacids, as certain antacids (those containing aluminum and/or magnesium) are not recommended to be taken with ISENTRESS.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please read the Patient Information , for ISENTRESS and discuss it with your doctor. The physician Prescribing Information also is available.

Brands mentioned are the trademarks of their respective owners.


INFC-1066246-0000 08/13